Kaepernick was sacked six times, intercepted once and held to 160 yards passing. He was also ineffective with his feet, rushing for 57 yards.
Meanwhile, Aaron Rodgers started fast and then slowly built the Packers’ lead. Rodgers completed 22 of 32 passes for 224 yards and one touchdown.
Eddie Lacy pounded out 90 yards rushing and helped kill the final four minutes of the game clock.
The Packers are 4-0 and return home for games against visiting St. Louis and San Diego prior to the Packers’ bye week.